Augustine Wianicho

There are many unique phrases used to describe the feeling of being under anaesthesia, including knocked out, going under, sedated, and put to sleep. The term anaesthesia refers to the loss of sensation.

The use of medications to prevent or minimize discomfort during a medical treatment is known as anesthesia.

Early anaesthetics incorporating opium poppy, mandrake fruit, and alcohol were described in ancient medical books from Egypt, Asia, and the Middle East.

Opium poppy(top left); Alcohol(bottom left); Mandrake fruit(right)

Local anaesthetics, which block pain signals from peripheral nerve endings to the central nervous system, and general anaesthetics, which operate on the central nervous system itself to cause coma and utter absence of feeling, are the two main types of medications.

Anaesthesia procedures are divided into three types.

1. Local anaesthesia: During a dental manipulation for example, a local anaesthetic is supplied directly to the operation site to multiple tiny locations such as a tooth.

2. Regional anaesthesia: a local anesthetic is administered near a group of nerve roots to block pain sensations in the area innervated by those nerves. This includes epidurals, which are administered to women during labor.

3. General anaesthesia: General anaesthesia involves the complete suppression of the central nervous system, resulting in loss of consciousness. A combination of medications is breathed, administered intravenously, or both. The first widespread inhalational anaesthetic was dimethyl ether. It was best known as a recreational drug until physicians realized that individuals didn't always detect injuries they had while using it. In the decades that followed, nitrous oxide grew popular and is still used today. For significant surgical operations, general anaesthesia is employed. Aside from pain relief, general anaesthesia has several additional objectives: it prevents the creation of new memories, relaxes muscles, and suppresses the autonomic reaction to surgical damage, which may otherwise be severe and dangerous. To attain these outcomes, general anaesthetics are frequently used in conjunction with other medicines. Propofol is an example of a general anesthetic medication. Propofol's specific method of action is unknown, however it is assumed to suppress cell response via binding to GABA receptors. In the central nervous system, GABA is a significant inhibitory neurotransmitter. When it binds, GABA receptors and gated chloride channels open, allowing chloride ions to enter into the neuron, hyperpolarizing it and making it less likely to activate. In other words, GABA reduces the sensitivity of brain cells to incoming inputs.

However, it is thought that a brain does not simply shut down while under anaesthetic. Instead, the brain's connections between various sections are destroyed. Several investigations have shown that an anaesthetized brain is nonetheless susceptible to stimuli like light and sound, but that this sensory information is somehow not processed, leaving no further repercussions. There are several distinct types of anaesthetic medications, each of which may target various chemicals in the brain. They can, however, cause unconsciousness if taken in large enough doses. This is likely due to the fact that awareness is the outcome of a complex network of brain operations, disruption of any of which might create network failure. Coming out of a coma isn't only a result of the medications wearing off and the connections between sections of the brain being destroyed. When they wake up, their brain must discover a method to reconnect them. This generally takes place in a certain order. The most fundamental and necessary processes, such as respiratory and digestive reflexes, are the first to return. After then, more complicated brain processes return. This might explain why it takes longer for older individuals and those with pre-existing neurological problems to regain all cognitive brain functions. In these individuals, the risk and severity of post-operative delirium, a condition of mental disorientation following surgery, are considerably increased. It's crucial to have the proper overall anesthetic dosage. The weight, age, and medical history of the patient are frequently used to compute it. The usage of recreational drugs in the past or present must also be considered, as this may influence the brain's susceptibility to anaesthetic medications. An overdose of anesthetic leads to a profound state of unconsciousness and, as a result, increased dangers such as potential long-term cognitive impairment and post-operative problems. A very low dose, on the other hand, may cause the patient to wake up during surgery, a condition called anaesthetic awareness, which can be a terrible experience for certain patients. According to various estimates, roughly one or two persons out of every 1,000 may be somewhat conscious during general anesthesia. Even rarely is the occurrence of pain, yet it can happen.

Anesthesiology is defined by the American Society of Anesthesiologists as: “The practice of medicine dedicated to the relief of pain and total care of the surgical patient before, during and after surgery.” An anesthesiologist is a doctor with specialized training in anesthesia. The anesthesiologist keeps track of your critical functions and maintains your breathing while you're asleep. The anesthesiologist is still in charge of your overall care after the surgery. They will reverse the anesthesia's effects and continue to monitor and keep you comfortable while you recover.

In as much as anaesthesia plays a very crucial role during surgery and other purposes, an overdose could be very fatal. Overall anesthesia-related mortality has increased in recent years.

According to a calculation based on data from 56 member states of the World Health Organization (WHO), some 230 million major surgical procedures are being carried out under anesthesia worldwide every year. In the industrialized nations, the estimated perioperative complication rate is 3% to 16%; in 0.4% to 0.8% (about 1 million patients) of all cases the result is lasting damage or death. Two studies have investigated the role of anesthesia-associated deaths.

On the basis of the ICD-10 codes that relate to anesthesia-associated complications, the authors of an epidemiological study in the United States evaluated death certificates from the years 1999 to 2005. In an estimated 105.7 million surgical cases, they found a total of 2211 anesthesia-related deaths and calculated an anesthesia-associated death rate of 8.2/1000000 hospital discharges. Of these deaths, 867 occurred in hospital, 348 in outpatient settings, 46 on admission to hospital, 258 after discharge, and 349 in a hospice or nursing home. No specific details were reported for the remaining deaths.

The percentage proportions are as follows:

  1. 46.6% of all deaths were associated with an anesthesia overdose

2. 42.5% of deaths were due to adverse effects of anesthetics that had been administered at therapeutic doses

3. 6% of all deaths were associated with pregnancy/obstetric care.

Anaesthesia is difficult to master, yet learning how to do so allows for the creation of new and improved surgical procedures. Surgeons might learn how to conduct Caesarean sections consistently and safely, unblock clogged arteries, and replace damaged livers and kidneys, among other life-saving procedures. Each year, new anaesthetic procedures are created to guarantee that an increasing number of patients survive surgery trauma.


  1. Mayo Clinic. Retrieved from:
  2. Medical News Today. Retrieved from:
  3. National Library of Medicine; National Center for Biotechnology Information. Retrieved from


Augustine Wianicho

A technological and astronomic enthusiast who seeks to inform about mind-blowing and developing technology and projects that are going to transform our lives and the world at large.